Studies on hydrocephalus and shunt therapies
Studies on hydrocephalus and shunt therapies—including MIETHKE shunt systems—provide important building blocks for modern, patient-oriented care.
Evidence-based therapy decisions: Validation of the efficacy and safety of various treatment options.
Long-term evaluations: insights into complications, revision rates, and patient-relevant outcomes.
Patient orientation: consideration of quality of life, everyday experiences, and subjective needs.
Promoting innovation: systematic testing and evaluation of new technologies and therapeutic approaches
This website provides a concise and structured overview of key publications and clinical studies. By compiling relevant research findings on MIETHKE products, the pathophysiology of hydrocephalus, and other important topics, we aim to consolidate knowledge - and provide guidance for specialists, patients, and anyone seeking in-depth information.
Title: PROSAIKA: a prospective multicenter registry with the firstprogrammable gravitational device for hydrocephalus shunting.
Link: https://pubmed.ncbi.nlm.nih.gov/26196478/
Citation: Kehler, U., Kiefer, M., Eymann, R., Wagner, W., Tschan, C. A., Langer, N., Rohde, V., Ludwig, H. C., Gliemroth, J., Meier, U., Lemcke, J., Thomale, U. W., Fritsch, M., Krauss, J. K., Mirzayan, M. J., Schuhmann, M., & Huthmann, A. (2015). PROSAIKA: a prospective multicenter registry with the firstprogrammable gravitational device for hydrocephalus shunting. Clinical neurology and neurosurgery, 137, 132–136. https://doi.org/10.1016/j.clineuro.2015.07.002
Title: Management of paediatric hydrocephalous with Miethke fixed pressuregravitational valves. The Alder Hey Children's Hospital experience.
Link: https://pubmed.ncbi.nlm.nih.gov/32020268/
Citation: Sokratous, G., Hadfield, O., Van Tonder, L., Hennigan, D., Ellenbogen, J., Pettorini, B., & Mallucci, C. (2020). Management of paediatric hydrocephalous with Miethke fixed pressuregravitational valves. The Alder Hey Children's Hospital experience. Child's nervous system : ChNS : official journal of theInternational Society for Pediatric Neurosurgery, 36(9), 2021–2025. https://doi.org/10.1007/s00381-020-04520-x
Title: The Impact of Intracranial Pressure Telesensors: An Observational Propensity-Matched Control Analysis of Service Demand and Costs.
Summary: The findings in this study suggest that telesensor implantation is associated with reduced healthcare service demand, institutional cost savings, and improved patient safety and experience.
Link: https://pubmed.ncbi.nlm.nih.gov/38445908/
Citation: Pandit AS, Kamal MA, Reischer G, Aldabbagh Y, Alradhawi M, Lee FMY, Sekhon PP, Moncur EM, Banks PDW, Thompson S, Thorne L, Watkins LD, Toma AK. The Impact of Intracranial Pressure Telesensors: An Observational Propensity-Matched Control Analysis of Service Demand and Costs. Neurosurgery. 2024 Mar 6;95(1):224–33. doi: 10.1227/neu.0000000000002893.
Title: Evaluation of Miethke M.scio Device Implantation for Intracranial Pressure Monitoring in Patients with Cerebrospinal Fluid Disorders.
Link: https://pubmed.ncbi.nlm.nih.gov/37506838/
Citation: Jirlow U, Arvidsson L, Magneli S, Cesarini K, Rostami E. Evaluation of Miethke M.scio Device Implantation for Intracranial Pressure Monitoring in Patients with Cerebrospinal Fluid Disorders. World Neurosurg. 2023 Nov;179:e63-e74. doi: 10.1016/j.wneu.2023.07.102.
Title: Maneuver protocol for outpatient telemetric intracranial pressuremonitoring in hydrocephalus patients.
Summary: This study provides an example of an outpatient telemetric ICP monitoring protocol.
Link: https://pubmed.ncbi.nlm.nih.gov/36098768/
Citation: Pennacchietti V, Schaumann A, Thomale UW. Maneuver protocol for outpatient telemetric intracranial pressuremonitoring in hydrocephalus patients. Childs Nerv Syst. 2023 Jan;39(1):185-195. doi: 10.1007/s00381-022-05659-5.
Title: The Sensor Reservoir - does it changemanagement?
Link: https://pubmed.ncbi.nlm.nih.gov/33587185/
Citation: Bjornson A, Henderson D, Lawrence E, McMullan J, Ushewokunze S. The Sensor Reservoir-does it changemanagement? Acta Neurochir (Wien). 2021 Apr;163(4):1087-1095. doi: 10.1007/s00701-021-04729-y.
Title: Intracranial Pressure-Guided Shunt Valve Adjustments with the Miethke Sensor Reservoir.
Link: https://pubmed.ncbi.nlm.nih.gov/29054776/
Citation: Antes S, Stadie A, Müller S, Linsler S, Breuskin D, Oertel J. Intracranial Pressure-Guided Shunt Valve Adjustments with the Miethke Sensor Reservoir. World Neurosurg. 2018 Jan;109:e642-e650. doi: 10.1016/j.wneu.2017.10.044.
Title: A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus (PENS).
Link: https://pubmed.ncbi.nlm.nih.gov/40960253/
Citation: Luciano, M. G., Williams, M. A., Hamilton, M. G., Katzen, H. L., Dasher, N. A., Moghekar, A., Hua, J., Malm, J., Eklund, A., Alpert Abel, N., Raslan, A. M., Elder, B. D., Savage, J. J., Barrow, D. L., Shahlaie, K., Jensen, H., Zwimpfer, T. J., Wollett, J., Hanley, D. F., Holubkov, R., … PENS Trial Investigators and the Adult Hydrocephalus Clinical Research Network (2025). A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus. The New England journal of medicine, 393(22), 2198–2209. https://doi.org/10.1056/NEJMoa2503109
Title: Safety and efficacy of gravitational shunt valves in patients with idiopathic normal pressure hydrocephalus: a pragmatic, randomised, open label, multicentre trial (SVASONA).
Summary: The SVASONA study showed that using gravitational instead of standard programmable shunt valves in iNPH patients dramatically reduced overdrainage complications—preventing roughly one such complication for every three patients treated.
Link: https://pubmed.ncbi.nlm.nih.gov/23457222/
Citation: Lemcke, J., Meier, U., Müller, C., Fritsch, M. J., Kehler, U., Langer, N., Kiefer, M., Eymann, R., Schuhmann, M. U., Speil, A., Weber, F., Remenez, V., Rohde, V., Ludwig, H. C., & Stengel, D. (2013). Safety and efficacy of gravitational shunt valves in patients with idiopathic normal pressure hydrocephalus: a pragmatic, randomised, open label, multicentre trial (SVASONA). Journal of neurology, neurosurgery, and psychiatry, 84(8), 850–857. https://doi.org/10.1136/jnnp-2012-303936
Title: Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT.
Summary: The BASICS trial evaluated the effectiveness of antibiotic-impregnated catheters to reduce infection risks in shunt surgeries.
Link: https://pubmed.ncbi.nlm.nih.gov/32238262/
Citation: Mallucci CL, Jenkinson MD, Conroy EJ, Hartley JC, Brown M, Moitt T, Dalton J, Kearns T, Griffiths MJ, Culeddu G, Solomon T, Hughes D, Gamble C; BASICS study collaborators. Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT. Health Technol Assess. 2020 Mar;24(17):1-114. doi: 10.3310/hta24170. PMID: 32238262; PMCID: PMC7184313.
Note: The external research studies cited on this website are provided for informational purposes only and do not claim to be exhaustive. Links to PubMed are provided so that readers can access the original scientific publications. Christoph Miethke GmbH & Co. KG makes no claim to ownership of these studies, and the inclusion of a link does not imply that the authors, publishers, or institutions associated with the study endorse our products or services. Responsibility for the content of the studies lies with the authors. The summaries or references presented here are not a substitute for professional medical advice, diagnosis, or treatment. If you have questions about a medical condition or before making decisions regarding your health, treatment, or the use of a product, always consult a qualified healthcare professional.
